Group 39

Tomorrow’s cancer breakthroughs today

Our Mission

Engineering the Future of Oncology

radiation therapy

Redefining Cancer

Empyrean Medical Systems was founded on a singular premise: that the convergence of physics, data science, and clinical insight could profoundly reshape the future of cancer care. What began as a personal mission has become a globally-minded enterprise, led by founder and CEO Kal Fishman, whose decades of medical device innovation are now directed toward the most urgent frontier in healthcare—radiation oncology.

When faced with the devastating personal impact of his wife’s leukemia diagnosis, Kal responded not with resignation, but with resolve—to build a company that could change what is possible for patients and providers alike. From our inception in Boca Raton, Florida in 2020, Empyrean has drawn together physicists, oncologists, engineers, and informaticists with a shared purpose: to accelerate the next generation of cancer-fighting technologies through scientific rigor and transformative design.

radiation therapy

Forging a New Paradigm

A breakthrough in particle physics catalyzed the formation of our Research and Clinical Devices division. This advancement soon led to the establishment of our Therapeutics and Informatics divisions, forming a triad of innovation that spans discovery and development. Each division drives a robust pipeline of solutions designed to reimagine cancer treatment.

Empyrean exists not just to compete—but to lead. We are forging a new paradigm in oncology, where precision, performance, and patient impact define every advancement.

Our Leadership Team

Kal Fishman

President & Chief Executive Officer

Mr. Fishman is a serial entrepreneur in the fields…

Liran Marelli

Chief Financial Officer. M.B.A, CPA

With over 20 years of experience in financial management,…

Johnathan Vainer

Chief Technology Officer

Before becoming Empyrean’s Chief Technology…

Dirk Bartkoski, M.Sc., Ph.D.

Chief Scientific Officer

Recently served as a computational scientist…

Jacob Scott, MD, DPhil

Med. Dir. & Chief Scientist, SAB Chair

Dr. Scott is a board-certified radiation oncologist…

Dror Alezra, M.Sc, Ph.D.

Chief Physicist

Recently served as Chief Physicist and Chairman at…

Our Board of Directors

Kal Fishman

President & Chief Executive Officer

Mr. Fishman is a serial entrepreneur in the…

Jack Ziffer, M.D., PhD.

Jack Ziffer, M.D., PhD. is a director of the Company….

Sue Wallace, PhD.

Sue Wallace, PhD. is a director of the Company…

Thomas Buchholz, M.D.

Thomas Buchholz, M.D. is a director of the Company…

L. Peter Smith

L. Peter Smith is a director of the Company…

Kerwin Brandt

Kerwin Brandt is a director of the Company…

David Romagnoli

David Romagnoli is a director of the company…

Steven S. Scott

Mr. Scott is the co-founded SkinCure Oncology…

Ryan S. Gish

Mr. Gish is a highly accomplished healthcare…

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  • Kal Fishman

    President & Chief Executive Officer

    When faced with the devastating personal impact of his wife’s leukemia diagnosis, Kal responded not with resignation, but with resolve—to build a company that could change what is possible for patients and providers alike.

    Kal Fishman

    President & Chief Executive Officer

    Mr. Fishman is a serial entrepreneur in the fields of radiation oncology and radiology. Mr. Fishman is the inventor of the robotically-assisted Morpheus™ beam sculpting image-guided radiotherapy system, which was taken from concept to FDA submission and clearance in approximately eighteen months and is Empyrean’s first commercial product. Before founding and launching Empyrean Medical Systems, Mr. Fishman was the co-founder and served as the Chief Technology Officer and Chief Operations Officer of Sensus Healthcare, Inc., a publicly traded company (Nasdaq®: SRTS) specializing in superficial, brachytherapy, and intraoperative oncological radiation therapy systems from 2010 to 2019. In addition, he held executive positions at other medical device companies, including GE Healthcare, Siemens Medical Systems, CTI, Elscint, Positron Medical Systems, and Rcadia Medical Imaging. He is a GE-certified Six-Sigma DFSS/DMAIC Black Belt. Before that, Mr. Fishman was a senior research and development engineer in the Israeli Air Force R&D Core at the Airborne Intelligence and Cryptography Division. Mr. Fishman holds over ten patents in radiation oncology, radiology, and bioinformatics. He also serves as the Chairman of the Board of Directors.

    Liran Marelli

    Chief Financial Officer. M.B.A, CPA

    With over 20 years of experience in financial management, Mr. Marelli is an experienced finance executive with demonstrated skills and knowledge that are instrumental in an organization’s strategic leadership. Highly skilled in Strategic Planning, Finance Operations, Planning and Budgeting, Accounting, and Corporate Governance. He began his career in Public Accounting at Ernst & Young. He continued a path of leading finance roles in several companies, from start-ups to multinational corporations, in the High-Tech, Fin-Tech, and pharmaceutical industries. He recently served as a CFO at a leading global pharmaceutical corporation, bringing his knowledge and experience to the management team, and leading the organization to significant growth, while improving costs and streamlining supply-chain operations. Mr. Marelli obtained accounting and MBA degrees from Florida Atlantic University and is a Certified Public Accountant in Florida and Israel.

    Johnathan Vainer

    Chief Technology Officer

    Before becoming Empyrean’s Chief Technology Officer, Mr. Vainer served as Chief Technology Officer at Sensus Healthcare (NASDAQ®: SRTS). Mr. Vainer brings extensive medical device and advanced technology research and development experience from his tenure at Sensus Healthcare and the organizations with which he held vital roles. He oversaw the development of smart aesthetic laser systems, superficial radiation therapy systems, cloud operating systems, electronic medical records (EMR) systems, and advanced treatment planning systems (TPS). In addition, Mr. Vainer has extensive experience in medical device regulatory submission and clearance and R&D programs management. Prior to that, Mr. Vainer was a software developer at Connecteam and a senior systems engineer at the Israeli Navy. Yonatan attended The School of Computer Science at Tel Aviv University, Israel.

    Dirk Bartkoski, M.Sc., Ph.D.

    Chief Scientific Officer

    Recently served as a computational scientist in the Department of Radiation Physics at the MD Anderson Cancer Center in Houston, Texas, Dr. Bartkoski is a co-inventor of the MOVHEET technology. He received his master’s in 2005 and doctorate in 2013 from the University of Tennessee, both in the field of particle accelerators, with research conducted at the Spallation Neutron Source at Oak Ridge National Laboratory. Transitioning to Medical Physics, he obtained a certificate in Medical Physics from the University of Texas, Graduate School of Biomedical Sciences at Houston. He completed a postdoctoral fellowship at MD Anderson in 2016. Dr. Bartkoski is specialized in developing multiple cancer treatment delivery technologies based on converging radiation beams. As Empyrean’s Chief Scientific Officer, Dr. Bartkoski oversees all the translational science work, particle ballistics simulation, next generation scientific and technological research and development, and the implementation of contemporary and future scientific breakthroughs in Empyrean’s product lines.

    Jacob Scott, MD, DPhil

    Med. Dir. & Chief Scientist, SAB Chair

    Dr. Scott is a board-certified radiation oncologist and physician-scientist at Cleveland Clinic. He serves as Associate Cancer Center Director for Data Science at Case Western Reserve University. He runs an NIH-funded laboratory studying evolutionary therapy – a field he has been pioneering to harness evolution to treat cancer and complex infections. As a world leader in evolutionary biology and cancer treatment, Dr. Scott brings years of experience and thought leadership to our team. He also holds the role of Adjunct Assistant Professor in the Department of Physics at Case Western Reserve University. Dr. Scott also specializes in the care of patients with Sarcoma. He is a theoretical biologist who thinks about and studies the fundamental evolutionary mechanisms driving therapeutic resistance in cancer and pathogens. While in the lab, he dedicates himself to finding new therapeutic paths to defeat cancer and spends his time working with and mentoring his lab researchers and students.

    Dror Alezra, M.Sc, Ph.D.

    Chief Physicist

    Recently served as Chief Physicist and Chairman at Sheba Medical Center’s radiotherapy department at Tel Hashomer, Israel, Dr. Alezra is the original inventor of the MOVHEET technology. As Chief Physicist at Empyrean, Dr. Alezra oversees all the translational physics research and development, product ideation, medical physics, treatment planning algorithms development, neuro-network training, and core systems physics of Empyrean’s radiation therapy technologies and product lines. Dr. Alezra is an accomplished researcher, a serial inventor, and a well-published scientist with over thirty-five international publications. Dr. Alezra received his BSc., M.Sc., and Ph.D. in Nuclear Physics from Ben Gurion University in Israel. Between 1999 and early 2020, Dr. Alezra served as the Chairman of the Israeli Association of Medical Physics. Dr. Alezra also served on many Scientific Advisory Boards of the industry’s leading companies and is a scientific consultant to several innovative startup companies in Israel. In addition, Dr. Alezra serves as an Adjunct Professor of Radiation Physics and Radiation Oncology at the University of Texas, MD Anderson Cancer Center, and as an Adjunct Senior Lecturer at the Ben-Gurion University of the Negev in Israel.

    Kal Fishman

    Chairman of the Board

    Mr. Fishman is the inventor of the Morpheus™ technology, which was taken from concept to FDA-submission and clearance in approximately eighteen months. Mr. Fishman is a serial entrepreneur in the field of radiation oncology and radiology. Prior to founding Empyrean, Mr. Fishman was the co-founder and served as the Chief Technology Officer and Chief Operations Officer of Sensus Healthcare, Inc., a publicly traded company (Nasdaq®: SRTS), specializing in superficial, brachytherapy, and intraoperative oncological radiation therapy systems from 2010 to 2020. He held executive positions at other medical device companies, including GE Healthcare, Siemens Medical Systems, CTI, Elscint, Positron Medical Systems, and Rcadia Medical Imaging. He is a GE-certified Six Sigma DFSS/DMAIC Black Belt. Prior to that, Mr. Fishman served as a senior research and development engineer in the Israeli Air Force R&D Core, at the Airborne Intelligence and Cryptography Division. Mr. Fishman holds over ten patents in the fields of radiation oncology, radiology, and bioinformatics. He also serves as the Chairman of the Board of Directors.

    Jack Ziffer

    M.D., PhD.

    Jack Ziffer, M.D., PhD. is a director of the Company. Dr. Ziffer serves as the Executive Vice President, Chief Clinical Officer, and Chief Physician Executive for Baptist Health South Florida, with responsibility for all strategic, operational and policy matters for Baptist Health’s physician initiatives and enterprises. In addition to Baptist Health Medical Group and Baptist Health Quality Network, Dr. Ziffer’s areas of oversight include population health, medical informatics and advanced analytics, the system’s pharmacy program, home health, as well as the Center for Research and Grants. A luminary physician leader, he was the founding leader of Baptist Health Medical Group (BHMG) as its first CEO. Prior to becoming a physician-executive at Baptist Health, Dr. Ziffer served as president and CEO of RASF, a multispecialty group and one of the largest in South Florida and among the largest in the nation for radiology. Prior to that, he was director of cardiovascular nuclear medicine at Emory University, where he first completed his residency in diagnostic radiology and then a combined fellowship in nuclear medicine and cardiovascular MRI. Dr. Ziffer is a Fellow of the American College of Cardiology, the American Heart Association, the American Society of Nuclear Cardiology, and a master of Society of Cardiovascular Computed Tomography. He is a Diplomate of the American Board of Radiology, including special competence in nuclear radiology, and the American Board of Nuclear Medicine. He has authored more than 100 articles, chapters and abstracts and given hundreds of lectures in the U.S. and abroad. He has served as a reviewer of numerous journals and on the editorial board of the Journal of Nuclear Cardiology. He is a clinical professor of radiology at Florida International University’s Herbert Wertheim College of Medicine.

    Sue Wallace

    PhD.

    Sue Wallace, PhD. is a director of the Company. Dr. Sue Wallace is the Chief Executive Officer of Voximetry Incorporated, an early phase Healthtech company. Educated in nuclear and radiopharmaceutical chemistry, Dr. Wallace has extensive experience in medical device R&D, commercialization, and global general management. Dr. Wallace is a valuable advisor to improve operational efficiency and drive commercial growth. She has proven success learning new technologies and adapting strategies within Fortune 500 companies, startups, early-stage ventures, or late life-cycle rescues. She has held executive leadership positions with GE Healthcare, Philips Healthcare, Cardinal Health, Abiomed, and Accuray. Dr. Wallace is a GE trained Six Sigma Master Black Belt. She holds a B.S. degree from the University of Wisconsin, and a Master of Science in Nuclear Chemistry & Doctorate in Radiopharmaceutical Chemistry from Washington University in St. Louis. She is best known as a highly intelligent, insightful visionary. She has been a frequent speaker on innovation and creating productive eco-systems. She currently resides in the San Francisco Bay area.

    Thomas Buchholz

    M.D.

    Thomas Buchholz, M.D. is a director of the Company. A renowned physician, researcher, and scholar, Dr. Buchholz serves as the Medical Director of the Scripps MD Anderson Cancer Center. In this role, Dr. Buchholz leads a comprehensive multidisciplinary and clinically integrated cancer research and care program. Prior to Scripps, Dr. Buchholz spent twenty years with the University of Texas MD Anderson program, holding a variety of academic and executive leadership positions. During his tenure he was division head and department chair of radiation oncology and served as Executive Vice President and Physician-in-Chief. Before his time at MD Anderson Cancer Center, Dr. Buchholz served as a major and radiation oncologist in the United States Air Force, where he created the first brachytherapy and stereotactic radiation program for the Department of Defense. He later went on to work in several teaching positions at the University of Washington and the University of Texas Health Science Center in San Antonio, Texas. Dr. Buchholz’s academic research includes a focus on clinical and translational research in breast cancer and radiation oncology. Additionally, he maintains a strong interest in the education and mentoring of junior faculty and trainees in clinical care and research. Dr. Buchholz earned his medical degree from Tufts University School of Medicine in Boston, Massachusetts. He later went on to complete his clinical residency in radiation oncology and research fellowship in radiobiology research at the University of Washington Medical Center. He is board certified by the American Board of Radiology and the National Board of Medical Examiners.

    L. Peter Smith

    Director of the Company

    L. Peter Smith is a director of the Company. Mr. Smith started his healthcare career at Baxter International, a diversified medical products and services company, from 1978-1990. While at Baxter, Mr. Smith served as Chief Operating Officer of Baxter’s Japanese Subsidiary located in Tokyo. Subsequently, he was the President of Baxter’s Caremark Division. In 1991, Mr. Smith founded and led CorSolutions, Inc., which became a leading national disease management company. CorSolutions was sold in 2005 to Matria Healthcare for an IRR of 25%. Mr. Smith also founded and led Medmark, Inc., a leading specialty pharmaceutical distribution company which was also sold in 2006 to Walgreens for an IRR of 45%. In the case of both CorSolutions and Medmark, Mr. Smith was responsible for developing the business plans and management teams and securing funding. During his career, Mr. Smith has served as a director of several public and private healthcare companies. He currently serves as a director for Matrix Medical Corporation, Smartpill Corporation, and E-O2 Concepts, Inc. Mr. Smith received his BA from Princeton University and his MBA from the University of Chicago.

    Kerwin Brandt

    Director of the Company

    Kerwin Brandt is a director of the Company. Mr. Brandt has over twenty-six years in healthcare financing and transactions, together with over twenty years of executive and operational leadership experience with various healthcare start-ups and business ventures. Mr. Brandt Served as the CEO of Accelitech for eleven years, which was the venture that helped launching and ramping up Accuray Oncology’s CyberKnife® robotic radiosurgery platform to market in its early and growth stages, prior to founding and serving as SkinCure Oncology’s CEO. Under his leadership, SkinCure Oncology pioneered and expanded the adoption and growth of high frequency ultrasound-guided superficial radiation therapy (IGSRT) for treating skin cancer and other skin auto-immune diseases in the cutaneous oncology market segment. Prior to that, Mr. Brandt served as the CFO of a venture-funded health services company. Mr. Brandt has an extensive M&A experience and track record and he had raised over $200 million in financing (debt and equity) in the healthcare space.

    David Romagnoli

    Director of the Company

    David Romagnoli is a director of the company. Mr. Romagnoli joined Seacoast Capital in 2013 and is a Partner in the Boston office. Previously, Mr. Romagnoli worked at Easterly Capital, a private equity firm in Beverly, MA where he focused on new investments. Prior to Easterly, he worked at Needham & Co in Boston as an Equity Research Associate. Mr. Romagnoli received a BS in Economics from Bates College and an MBA from the Booth School of Business at the University of Chicago, graduating with honors.

    Steven S. Scott

    co-founded SkinCure Oncology

    Mr. Scott is the co-founded SkinCure Oncology with a long career in healthcare and business management. He previously served as COO of Tru-Skin Dermatology in Austin, Texas, and held various executive positions at The Centers for Cancer Care in San Marcos, Texas; before that, Mr. Scott served as vice president of North Cypress Medical Center and was involved in management, planning, construction, and development, ultimately responsible for over $150M annually in service-line revenues; Mr. Scott served as strategic account manager for Varian Medical Systems, and HCA in Houston and at other prominent cancer treatment facilities. Mr. Scott has also built more than ten radiation oncology facilities, has strong dermatology and radiation oncology center management skills, and claims integrity expertise.

    Mr. Scott earned his Master of Healthcare Administration degree at Forbes School of Business-Ashford University. He is a Board-Certified Radiologic Technologist in Radiation Therapy and a member of the American Registry of Radiologic Technologists and the American Society of Radiologic Technologists. He resides in Central Texas with his wife Ellen and daughter Emma.

    Ryan S. Gish

    Healthcare Executive

    Mr. Gish is a highly accomplished healthcare executive with nearly thirty years of experience in the industry. He is currently a Managing Director at Kaufman Hall, where he has worked for the past 20+ years and formerly served as the co-lead of the strategy and financial planning practices. Mr. Gish is known for his ability to assist boards and leaders in addressing pressing industry challenges through defining and implementing resilient strategies for the changing healthcare landscape. He is a trusted advisor who has advised leading national health systems, health plans, private equity-backed start-ups, academic medical centers, and multispecialty physician practices.

    Prior to joining Kaufman Hall, Mr. Gish worked at Jennings Ryan & Kolb and Baxter Healthcare Corporation. As a special advisor to the CEO and Board of SkinCure Oncology, Mr. Gish provided invaluable guidance and counsel in navigating strategic decisions concerning disruptive technology and its impact on market positioning, supplier relationships, and overall strategic goals.

    Mr. Gish is a sought-after speaker and author on healthcare issues and opportunities. He has spoken at seminars sponsored by organizations such as the American College of Healthcare Executives, American Hospital Association, Healthcare Financial Management Association, and The Governance Institute. He served on the Board of Directors for the Society for Healthcare Strategy and Market Development for six years and has been a guest faculty at prestigious institutions such as Harvard University, Washington University in St. Louis, and The University of Southern California. Mr. Gish received his Bachelor of Science in Mechanical Engineering, cum laude, and his M.B.A., with honors, from Washington University in St. Louis. He is an active supporter of civic and charitable organizations including Bernie’s Book Bank, LINK Unlimited Scholars, and MetroSquash. Ryan resides in Lake Forest, Illinois, with his wife and three children, and remains committed to making a positive impact on the healthcare industry and beyond.

    Val Graceffa

    Chief Commercial Officer

    Ms. Graceffa is a seasoned Commercial leader with over 15 years of experience building effective, patient-focused, and revenue-generating teams. She has successfully launched and re-launched over ten medical products and services throughout her career. Ms. Graceffa has established and successfully led best-in-class Sales, Marketing, Analytics, Business Operations, Recruiting, Corporate Development, and Training departments. She has also led Corporate Strategy, Investor Communications, and Project Management and has executed several successful Business Development transactions. Prior to joining Empyrean Medical Systems, Ms. Graceffa was one of the first commercial hires at RedHill Biopharma, where she served as the Vice President of Sales and Marketing. She successfully established their US Commercial team and is known for her innovation, key-stakeholder alignment, growth mindset, cross-functional collaboration, and strategic partnerships. Ms. Graceffa founded and developed her consulting company, MyPalVal, LLC., based out of San Francisco in 2016. Previously she has also served as a Sales and Marketing leader at Aurora Diagnostics, Warner Chilcott Pharmaceuticals, and the TRAK Group.